Dimethyl silicone oil: A dual Engine from industrial lubricants to life sciences and sustainable development

1.Revolutionary progress has been made in organ preservation technology
The latest research shows that the antifreeze organic gel interface composed of nanoscale polydimethylsiloxane (PDMS) and dimethyl silicone oil has successfully achieved quasi-uniform ultra-cold preservation of mouse hearts at -4 ℃, with the preservation time exceeding 72 hours. This technology builds an energy barrier close to homogeneous nucleation, eliminates the formation sites of ice nuclei, and does not require traditional cryoprotectants or machine perfusion systems, doubling the effective preservation time of heart transplants compared to clinical hypothermia methods. Experimental data show that the re-beating rate of the heart still reached 100% after 36 hours of preservation. Three months after transplantation, the blood flow velocity increased by 50% compared with the control group, and the degree of myocardial fibrosis decreased by 15%. This achievement offers a brand-new approach to addressing the global shortage of organ donors and is expected to enter the clinical trial stage within the next 3 to 5 years.

2. Pharmaceutical-grade products drive the upgrading of treatment for digestive system diseases
The 2025 edition of the Chinese Pharmacopoeia officially included pharmaceutial-grade dimethyl silicone oil in the standards, raising its purity requirement to over 99% and keeping the endotoxin content below 0.25EU/mL. As a gastrointestinal lubricant and anti-foaming agent, pharmaceutical-grade silicone oil can significantly improve the clarity of the field of view during gastroscopy and reduce the discomfort of patients. In the field of pharmaceutical preparations, as a carrier material, it can enhance the stability of active ingredients. For instance, adding 0.1% to 0.3% of dimethyl silicone oil to oral suspensions can reduce the sedimentation rate of drug particles by 60% and prolong the release time of active ingredients. At present, many domestic medical institutions have adopted it for the prevention of postoperative intestinal adhesions, with a clinical effective rate of over 85%.

3. Bio-based alternative technologies usher in a new era of green production
The world's first 100% bio-based dimethyl silicone oil (Silway350) has officially entered mass production. During its production process, fossil raw materials are completely replaced by renewable bio-methanol. This product maintains the excellent performance of traditional silicone oil while having a volatile organic compound (VOC) content of less than 50g/L, meeting the requirements of the EU REACH regulation. Test data shows that its surface tension reaches 21.5mN/m, the freezing point is as low as -65 ℃, and the performance fluctuation within the temperature range of -50 ℃ to 200℃ is less than 3%. It is expected that by 2030, the market share of bio-based products will increase from the current 10% to 15%, driving a 12% reduction in the industry's carbon emission intensity.

4. High-end applications drive the reconstruction of industry value
In the field of electronic packaging, domestic high-purity dimethyl silicone oil (with a metal ion content of less than 1ppb) has passed the tests and verifications of multiple semiconductor enterprises and successfully replaced imported products in the production of heat dissipation gels for 5G base station chips. The demand for high-temperature resistant silicone oil (with a long-term operating temperature above 300℃) in the battery thermal management system of new energy vehicles has soared. It is estimated that the related market size will exceed 3 billion yuan by 2025. At the policy level, the "Guidance Catalogue for the First Batch Application Demonstration of Key New Materials" has listed high-performance silicone materials as an encouraged project. Enterprises that meet the conditions can receive a research and development subsidy of up to 15%.